By K. Kitagawa, D. R. Colman (auth.), S. Salvati (eds.)

ISBN-10: 146136034X

ISBN-13: 9781461360346

ISBN-10: 1461524350

ISBN-13: 9781461524359

The illnesses that fall less than the generalized crew of demyelinating ailments -Multiple Sclerosis, Leukodystrophyes, Encephalomyelitis-are the point of interest of globally main issue. This quantity includes papers offered by means of best scientists who attended the NATO complicated learn Workshop held on the Istituto Superiore di SanitA, Rome, March 1-4, 1993. This e-book is an replace of the former one released in 1987 of the examine mentioned at an identical assembly held in 1986. It used to be determined to carry this 2d assembly seeing that there was nice growth within the advances in figuring out the myelinogenesis strategy within the final 5 years. The workshop amassed jointly scientists from many fields comparable to mobile and molecular biology, immunology, pathology, virology and naturally medical neurology. Stimulating principles have been exchanged within the desire that extra wisdom of demyelinating illnesses can result in new theraupetic methods. even supposing the workshop used to be commonly just like the former one, this time there has been extra emphasis on experimental versions and medical features. within the former using animal and mobile versions as instruments for figuring out the pathological mechanisms associated with human affliction have been mentioned; within the latter the clinicians defined the filtering down of uncomplicated examine to medical remedy The ebook of this interdisciplinary alternate is to make recognized the result of the latest learn one of the investigators from allover the realm all for those studies.

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Expression of a novel transcript of the myelin basic protein. J. Neurochem. 54: 2032-2041 (1990). 8. , and Mikoshiba, K. The promoter elements of the mouse myelin basic protein gene function efficiently in NGl08-15 neuronal/glial cells. Gene 75:31-38 (1989). 9. , and Mikoshiba, K. Core promoter of the mouse myelin basic protein gene governs brain-specific transcription in vitro. Embo J. 9:3101-3108 (1990). 10. , and Khalili, K. Analysis of the proximal transcriptional element of the myelin basic protein gene.

In contrast, oligodendrocytes that had not yet started to myelinate, or were just starting to enwrap axonal processes were clearly labeled with the anti-MBP antibodies. These MBP+ oligodendrocytes were not B-galactosidase+, suggesting a delay in the expression of the transgene as compared to the expression of the MBP itself. To explore this observation in more detail, we analyzed the expression of the transgene in mixed primary cultures. Brains from E15 transgenic embryos were dissociated, seeded on class coverslips and maintained in culture.

BioI. 113:1385-1397 (1991). 23. , and Zalc B. Clonal segregation of oligodendrocytes and astrocytes during in vitro differentiation of progenitor cells. Glia 6:289-300 (1992). 24. T. Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells. Cell 68:451-464 (1992). , 1993). Due to the separate occasions leading to the identification of this gene different names have been given for PMP22 cDNAs in the literature. , 1992). , 1990). , 1991).

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A Multidisciplinary Approach to Myelin Diseases II by K. Kitagawa, D. R. Colman (auth.), S. Salvati (eds.)


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