By Wenfei Jin

ISBN-10: 9401774064

ISBN-13: 9789401774062

ISBN-10: 9401774080

ISBN-13: 9789401774086

ISBN-10: 9535105884

ISBN-13: 9789535105886

In this thesis, Dr. Jin offers the distribution of ancestral chromosomal segments within the admixed genome, that may give you the info had to discover inhabitants admixture dynamics. the writer derives actual inhabitants histories of African american citizens and Mexicans utilizing genome-wide unmarried nucleotide polymorphisms (SNPs) facts. Mapping the genetic history enables the examine of ordinary choice within the admixed inhabitants, and the writer identifies the indications of choice in African americans considering that their African ancestors left for the USA. He extra demonstrates that a number of the choice indications have been linked to African American-specific high-risk ailments reminiscent of prostate melanoma and high blood pressure, suggesting an immense position those disease-related genes may have performed in adapting to their new setting. finally, the writer unearths the complexity of typical choice in shaping human susceptibility to ailment. The thesis considerably advances our realizing of the hot inhabitants admixture, edition to neighborhood surroundings and its healthiness implications.

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Association studies for next-generation sequencing. Genome Res. 2011;21:1099–108. Gorlov IP, Gorlova OY, Sunyaev SR, Spitz MR, Amos CI. Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. Am J Hum Genet. 2008;82:100–12. Li B, Leal SM. Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am J Hum Genet. 2008;83:311–21. Li Y, Byrnes AE, Li M. To identify associations with rare variants, just WHaIT: weighted haplotype and imputation-based tests.

23] the admixed population per generation, so that the cumulative genetic c­ ontribution from both parental populations is equal to that under HI model and GA model. The gene flow that the admixed population receives from the genetic donor per generation is calculated using α = 1 − (m)1/T. Because the parental populations play different roles in the admixture process in CGF model, the parental population acting as genetic donor was referred to as CGFD, while the parental population acting as genetic recipient was referred to as CGFR.

Genome Res. 2004;14:1076–84. Pritchard JK, Donnelly P. Case-control studies of association in structured or admixed populations. Theor Popul Biol. 2001;60:227–37. Seldin MF, Pasaniuc B, Price AL. New approaches to disease mapping in admixed populations. Nat Rev Genet. 2011;12:523–8. Zhu X, et al. Admixture mapping for hypertension loci with genome-scan markers. Nat Genet. 2005;37:177–81. Freedman ML, et al. Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men.

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Admixture Dynamics, Natural Selection and Diseases in Admixed Populations by Wenfei Jin

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